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thyroid follicular carcinoma

Clinical synopsis

- Mainly adults / rare in children
- Thyroidal mass lesion

Morphological synopsis

- Mass lesion within thyroid
- Usually solid
- Encapsulated or infiltrating
- Vascular and lymphatic spread
- Follicular architecture
- No characteristic nuclei of papillary carcinoma

  • Nuclei usually round / ovoid and bland
  • nuclear atypia does not necessarily relate to aggressive behavior

Variants

- Minimally invasive and widely invasive

  • depending on extent of
    • capsular invasion
    • vascular invasion (beyond capsule)

- oncocytic thyroid follicular carcinoma
- clear cell thyroid follicular carcinoma

Immunohistochemical staining

- Cytokeratin+
- Thyroglobulin+
- TTF-1+
- Ck19+
- Bcl2+
- Beta catenin+
- Chromogranin−

See also

- thyroid carcinomas

  • thyroid follicular carcinoma
  • thyroid poorly differentiated carcinoma
  • thyroid anaplastic carcinoma
  • thyroid squamous carcinoma
  • thyroid mucoepidermoid carcinoma
  • thyroid mucinous carcinoma