post-translational proteic modifications
Post-translational modifications define the functional and structural plasticity of proteins in archaea, prokaryotes and eukaryotes.
Multi-site protein modification modulates protein activity and macromolecular interactions and is involved in a range of fundamental molecular processes.
Types
proteic glycosylation
- O-linked N-acetylglucosamine (GlcNAc) glycosylation
proteic methylation
proteic acetylation
proteic nitration
proteic ubiquitylation
proteic farnesylation
proteic palmitoylation
proteic phosphorylation (PO4)
proteic transglutamination
proteic prenylation
proteic carboxyl methylation by methyltransferase
endoproteolytic processing by protease
References
Jensen ON. Interpreting the protein language using proteomics. Nat Rev Mol Cell Biol. 2006 Jun;7(6):391-403. PMID: #16723975#
Seet BT, Dikic I, Zhou MM, Pawson T. Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol. 2006 Jul;7(7):473-83. PMID: #16829979#
Drenth JP, Martina JA, van de Kerkhof R, Bonifacino JS, Jansen JB. Polycystic liver disease is a disorder of cotranslational protein processing. Trends Mol Med. 2005 Jan;11(1):37-42. PMID: #15649821#
Rehfeld JF, Goetze JP. The posttranslational phase of gene expression: new possibilities in molecular diagnosis. Curr Mol Med. 2003 Feb;3(1):25-38. PMID: #12558072#