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ultraviolet-signature mutations
Sunday 10 April 2016
UV signature
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The Molecular Perspective: Ultraviolet Light and Pyrimidine Dimers
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Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation. Harms PW, Collie AM, Hovelson DH, Cani AK, Verhaegen ME, Patel RM, Fullen DR, Omata K, Dlugosz AA, Tomlins SA, Billings SD. Mod Pathol. 2016 Mar;29(3):240-8. doi : 10.1038/modpathol.2015.154 PMID: 26743471 (Free)
Murine melanomas accelerated by a single UVR exposure carry photoproduct footprints but lack UV signature C>T mutations in critical genes. Mukhopadhyay P, Ferguson B, Muller HK, Handoko HY, Walker GJ. Oncogene. 2015 Oct 19. doi : 10.1038/onc.2015.386 PMID: 26477315 (Free)
In Vivo Spectrum of UVC-induced Mutation in Mouse Skin Epidermis May Reflect the Cytosine Deamination Propensity of Cyclobutane Pyrimidine Dimers. Ikehata H, Mori T, Yamamoto M. Photochem Photobiol. 2015 Nov;91(6):1488-96. doi : 10.1111/php.12525 PMID: 26335024 (Free)
UV signature mutations. Brash DE. Photochem Photobiol. 2015 Jan-Feb;91(1):15-26. doi : 10.1111/php.12377 PMID: 25354245 (Free)
Remarkable induction of UV-signature mutations at the 3’-cytosine of dipyrimidine sites except at 5’-TCG-3’ in the UVB-exposed skin epidermis of xeroderma pigmentosum variant model mice. Ikehata H, Chang Y, Yokoi M, Yamamoto M, Hanaoka F. DNA Repair (Amst). 2014 Oct;22:112-22. doi : 10.1016/j.dnarep.2014.07.012 PMID: 25128761
Molecular pathology of skin neoplasms of the head and neck. Kraft S, Granter SR. Arch Pathol Lab Med. 2014 Jun;138(6):759-87. doi : 10.5858/arpa.2013-0157-RA PMID: 24878016