hyalinoid giant cell gastritis

This degenerative and inflammatory lesion of the stomach clinically simulate gastric carcinoma because of the extensive involvement of the mucosa and submucosa by the process.

Histologically, it is characterized by eosinophilic hyalinoid degeneration of smooth muscles in the muscularis mucosae as well as mucosal and submucosal blood vessels accompanied with foreign body giant cells and other inflammatory cells.

The lesion occurred in association with chronic peptic ulcers, and a small submucosal nodule histologically compatible with inflammatory fibroid polyp coexisted within the area of this lesion.

The term "hyalinoid giant cell gastritis" has been proposed to describe this distinctive form of gastritis.

Reference

 Hyalinoid giant cell gastritis. A unique gastric lesion associated with eosinophilic hyalinoid degeneration of smooth muscle. Hanada M, Takami M, Hirata K, Nakajima T. Acta Pathol Jpn. 1985 May;35(3):749-58. PMID: 2412393