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DPYD
Saturday 23 January 2016
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Dihydropyrimidine dehydrogenase [NADP+] is an enzyme that in humans is encoded by the DPYD gene.
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism.
Pathology
Genetic deficiency of this enzyme results in an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy.