transmembrane domain proteins
Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes.
Members
G-protein coupled receptors (GPCRs)
growth factor receptors
ion channels
transporters
metabolic enzymes
Pathology
pathology of G-protein coupled receptors (GPCRs)
pathology of growth factor receptors
pathology of ion channels (channelopathies)
pathology of transporters
pathology of metabolic enzymes
References
Cobbold C, Monaco AP, Sivaprasadarao A, Ponnambalam S. Aberrant trafficking of transmembrane proteins in human disease. Trends Cell Biol. 2003 Dec;13(12):639-47. PMID: #14624842#