ciliated muconodular papillary tumor

Ciliated muconodular papillary tumors (CMPTs) are rare peripheral nodules of the lung first described in 2002.

Histologically, CMPTs showed glandular and/or papillary architecture, comprising a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, often enveloped by copious intra-alveolar mucin.

Micropapillary tufts of ciliated cells and seemingly discontinuous growth along alveolar walls were occasionally present, mimicking adenocarcinomas.

Ciliated cells and basal cells were immunopositive for TTF-1 and p40, respectively, whereas mucous cells lacked HNF4α expression.

CMPTs are rare, likely benign, underrecognized processes of the lung that should be distinguished from adenocarcinomas.

References

 Ciliated Muconodular Papillary Tumors of the Lung: A Clinicopathologic Analysis of 10 Cases. Kamata T, Yoshida A, Kosuge T, Watanabe SI, Asamura H, Tsuta K. Am J Surg Pathol. 2015 Mar 20. PMID: 25803171