pulmonary fibroadenoma

Definition: Pulmonary adenofibroma is a rare benign biphasic tumor of the lung composed of epithelial and stromal components. Pulmonary adenofibromas have variously been interpreted as hamartomas or as pseudopapillary variants of solitary fibrous tumour.

These are tumours of middle aged adults.

Macroscopy

These are solitary peripheral "coin" lesions.

Microscopy

There are large pseudopapillae covered by bland cuboidal epithelium. The stroma is fibrous, containing bland spindle cells. There is a resemblance to adenofibroma of the female genital tract.

Differential diagnosis

 solitary fibrous tumour with entrapped glands: in adenofibroma the glands are more evenly distributed.

 pleuropulmonary blastoma

Prognosis

Benign

References

 Pulmonary adenofibroma: clinicopathological study of 3 cases of a rare benign lung lesion and review of the literature. Kumar R, Desai S, Pai T, Pramesh CS, Jambhekar NA. Ann Diagn Pathol. 2014 Aug;18(4):238-43. doi : 10.1016/j.anndiagpath.2014.04.002 PMID: 24908371

 Cavazza A, Rossi G, De Marco L, et al. [Solitary fibrous pseudopapillary tumor of the lung: pulmonary fibroadenoma and adenofibroma revisited]. Pathologica 2003; 95:162-6

 Suster S,Moran CA Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. Histopathology 1993; 23:547-51