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IDH1-R132H IHC
Wednesday 25 February 2015
IHC for IDH1-R132H is relatively sensitive and specific, but there is a discordance rate that is not trivial, with NGS mutation profiling. In addition, a significant proportion of patients harbor IDH1 non-R132H mutations not detectable by IHC, potentially limiting utility of IHC screening for IDH1 mutations.
References
Comparison of Next-generation Sequencing Mutation Profiling With BRAF and IDH1 Mutation-specific Immunohistochemistry. Jabbar KJ, Luthra R, Patel KP, Singh RR, Goswami R, Aldape KD, Medeiros LJ, Routbort MJ. Am J Surg Pathol. 2015 Jan 28. PMID: 25634750