gastric endocrine dysplasia

Synopsis

• defined as large confluent micronodules of ECL cells lying deep in the mucosa, ranging from 150 to 500 microns in size.
• microinfiltration of the lamina propria may be present.
• newly formed stroma is occasionaly noted.
• when the nodules are larger than 0.5 mm and confined to the mucosa, they are classified as microcarcinoids (or intramucosal carcinoid tumors).

Case reports

 http://www.universitypathologists.com/education/case-of-the-month/may-2010

References

 Bordi C, et al. Hypergastrinemia and gastric enterochromaffin-like-cell proliferations of the gastric mucosa: classification and histogenesis. Am J Surg Pathol 1995;19(Suppl):S8-S19.

 Hyperplastic, dysplastic, and neoplastic enterochromaffin-like-cell proliferations of the gastric mucosa. Classification and histogenesis. Solcia E, Fiocca R, Villani L, Luinetti O, Capella C. Am J Surg Pathol. 1995;19 Suppl 1:S1-7. PMID: 7762735

 Solcia E, et al. Enterochromaffin-like (ECL) cells and their growths: relationship to gastrin, reduced acid secretion and gastritis. Bailliere’s Clin Gastroenterol 1993;7:149-165.

 Gastric endocrine cell hyperplasia and carcinoid tumors in atrophic gastritis type A. Müller J, Kirchner T, Müller-Hermelink HK. Am J Surg Pathol. 1987 Dec;11(12):909-17. PMID: 3318512

 Harvey RF, et al. Multifocal gastric carcinoid tumors, achlorhydria, and hypergastrinemia. Lancet 1985;951-54.

 Moses RE, et al. The syndrome of Type A chronic atrophic gastritis, pernicious anemia, and multiple gastric carcinoids. J Clin Gastroenterol 1986;8:61-65.