high-grade dysplasia in Barrett esophagus

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 http://www.webpathology.com/image.asp?n=6&Case;=185

Dysplasia in Barrett esophagus is dividied into low-grade and high-grade. Dysplastic changes are most often seen in the areas of incomplete intestinal metaplasia.

In high-grade dysplasia, he glands are crowded and irregularly shaped and there is nuclear hyperchromasia, increased mitotic activity, and prominent nucleoli.