KRT20

Immunochemistry

 colorectal adenocarcinoma

• The most common immunophenotype of colorectal adenocarcinoma is positivity for CK20 and negativity for CK7, which is a relatively specific staining pattern for colorectal origin.
• However, up to 20% of the tumors may exhibit a CK7-positive/CK20 negative or CK7-negative/CK20-negative staining pattern.
• It has been suggested that reduced or absent CK20 expression in colorectal carcinoma is associated with MSI-H.