FOXs
Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes.
As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression.
Forkhead-box (FOX) superfamily genes are implicated in carcinogenesis through gene amplification, retroviral integration and chromosomal translocation.
Members
FOX superfamily genes within the human genome are classified into 17 or 18 families, designated FOX# (# is alphabet A-Q or R).
| FOXAs | FOXBs | FOXCs | FOXDs | FOXEs | FOXFs | FOXGs | FOXHs |
| FOXIs | FOXJs | FOXKs | FOXLs | FOXMs | FOXNs | FOXOs | FOXPs |
Pathology (Examples)
FOX01A (FKHR) (MIM.136533)
- gene fusion PAX3/FOX01A in alveolar rhabdomyosarcoma by t(12;13)
References
Mercado GE, Barr FG. Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances. Curr Mol Med. 2007 Feb;7(1):47-61. PMID: #17311532#
Myatt SS, Lam EW. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer. 2007 Nov;7(11):847-59. PMID: #17943136#
Lehmann OJ, Sowden JC, Carlsson P, Jordan T, Bhattacharya SS. Fox’s in development and disease. Trends Genet. 2003 Jun;19(6):339-44. PMID: #12801727#