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sclerosing adenosis
Wednesday 4 July 2012
sclerozing adenosis of the breast, mammary sclerosing adenosis; Fibrosclerosis of breast
| PO | WP |
Definition: Sclerosing adenosis has sclerosis, increased glands and stromal growth compressing the glands; on low power it shows a lobulated outline and a myoepithelial layer.
Images
Wikimedia: sclerosing adenosis of the breast.
sclerosing adenosis and collagenous spherulosis
Digital cases
JRC:5279 : sclerosing adenosis of the breast.
JRC:5280 : sclerosing adenosis of the breast.
JRC:5283 : sclerosing adenosis of the breast.
JRC:5287 : sclerosing adenosis of the breast.
Microscopy
Sclerosing adenosis has a lobulated outline and a myoepithelial layer. It can be easiest to differentiate it from carcinoma on low power from its lobular outline.
The enlarged lobule undergoes fibrosis.
Multiple microcalcifications present as purple, round bodies.
proliferation of myoepithelial cells and stromal fibrosis.
Microcalcifications have a laminated, purple appearance.
At late stage
- acini begin to decrease in number.
- Atrophic acini are surrounded by abundant fibrous stroma.
Differential diagnosis
Sclerosing adenosis has a lobulated outline and a myoepithelial layer.
See also
breast diseases
breast lesions
- adenosis