RB/E2F pathway
Functions
The Rb/E2F pathway is critical in regulating the initiation of DNA replication.
The pathway controls the activity of the retinoblastoma tumor suppressor protein (RB), which in turn regulates the E2F transcription factor.
The Rb/E2F pathway is critical in regulating the initiation of DNA replication.
The control of the Rb/E2F pathway is disrupted in virtually all human cancers.
References
Calzone L, Gelay A, Zinovyev A, Radvanyl F, Barillot E. A comprehensive modular map of molecular interactions in RB/E2F pathway. Mol Syst Biol. 2008;4:173. PMID: #18319725#
Reviews
DeGregori J, Johnson DG. Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med. 2006 Nov;6(7):739-48. PMID: #17100600#
Johnson DG, Degregori J. Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context. Curr Mol Med. 2006 Nov;6(7):731-8. PMID: #17100599#
Korenjak M, Brehm A. E2F-Rb complexes regulating transcription of genes important for differentiation and development. Curr Opin Genet Dev. 2005 Oct;15(5):520-7. PMID: #16081278#
Nevins JR. The Rb/E2F pathway and cancer. Hum Mol Genet. 2001 Apr;10(7):699-703. PMID: #11257102#