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alloimmune neonatal hemochromatosis
Friday 16 September 2011
Alloimmune liver disease is sometimes associated with fetal death.
Synopsis
neonatal hemochromatosis
neonatal acute liver failure
acute liver injury
- global hepatocyte necrosis
- minimal reticulum collapse
- no fibrosis.
Hepatocytes stain strongly positively for C5b-9 complex suggesting pre-mortem lgG complement-mediated liver injury.
Hepatocytes in acute liver failure case controls do not demonstrate a similar mechanism of liver injury.
References
Gestational Alloimmune Liver Disease in Cases of Fetal Death. Whitington PF, Pan X, Kelly S, Melin-Aldana H, Malladi P. J Pediatr. 2011 May 16. PMID: 21592512
Novel mechanism of fetal hepatocyte injury in congenital alloimmune hepatitis involves the terminal complement cascade. Pan X, Kelly S, Melin-Aldana H, Malladi P, Whitington PF. Hepatology. 2010 Jun;51(6):2061-8. PMID: 20512994