gastric hepatoid adenocarcinoma
Histologically, the polygonal tumor cells are arranged in trabecular fashion or solid nests separated by narrow fibrous stroma composed of sinusoid-like capillaries.
Immunohistochemically, the tumor cells are positive for α-fetoprotein.
Under transmission electron microscope, numerous circular granules of dense electron were found in the cytoplasm.
HAS showed a higher rate of vascular invasion, lymph node metastasis, and liver metastasis than non-HAS.
The 5-years survival rates of hepatoid adenocarcinoma of the stomach (HAS) and non-hepatoid adenocarcinoma of the stomach (non-HAS) were 9% and 44%, respectively. The prognosis of HAS was poorer than that of non-HAS (P<0.05).
References
Analysis of clinicopathologic features and prognostic factors in hepatoid adenocarcinoma of the stomach. Liu X, Cheng Y, Sheng W, Lu H, Xu X, Xu Y, Long Z, Zhu H, Wang Y. Am J Surg Pathol. 2010 Oct;34(10):1465-71. PMID: #20871221#