adrenal epithelioid angiomyolipoma
Epithelioid angiomyolipoma (AML) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis.
Extrarenal AMLs are rare.
Synopsis
adrenal mass
epithelioid smooth muscle cells
- slightly pleomorphic nuclei
- sometimes with prominent nucleoli
- eosinophilic cytoplasm resembling oncocytic tumors.
Immunochemistry
Epithelioid cells were positive for melanoma (HMB45 and positive MelanA) and smooth muscle markers (alpha-smooth muscle-specific actin), but not for epithelial markers (cytokeratin, EMA).
Differential diagnosis
renal cell carcinoma
adrenal gland carcinoma
metastatic carcinoma
References
Monotypic epithelioid angiomyolipoma of the adrenal gland: an unusual site for a rare extrarenal tumor. D’Antonio A, Caleo A, Caleo O, De Dominicis G, Boscaino A. Ann Diagn Pathol. 2009 Oct;13(5):347-50. PMID: #19751913#