mammary Erdheim-chester disease
Erdheim-Chester disease is a rare non-Langerhans cell histiocytosis of unknown etiology, the commonest sites of involvement being the long bones, skin, orbit, pituitary and retroperitoneum. Breast involvement is rare. (#20216377#)
SYnopsis
diffuse xanthomatous infiltrate with scattered Touton-type giant cells
patchy lymphocytic infiltrate.
The cells are CD68 positive, and negative for S100, CD1a and a broad panel of cytokeratins.
Perivascular infiltration is also a rare but recognized presentation of Erdheim-Chester disease.
Histiocytic proliferations including ECD can mimic breast carcinoma clinically, radiologically, and histologically, and should be considered in the differential diagnosis of breast mass lesions. (#20216377#)
See also
Erdheim-Chester disease
References
Erdheim-chester disease presenting as bilateral clinically malignant breast masses. Provenzano E, Barter SJ, Wright PA, Forouhi P, Allibone R, Ellis IO. Am J Surg Pathol. 2010 Apr;34(4):584-8. PMID: #20216377#