SIRTs
Sirtuin deacetylases are linked to longevity, aging, and stress responses.
Members
SIRT1, SIRT2, SIRT3
SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.
References
A tumor suppressor SIRTainty. Schumacker PT. Cancer Cell. 2010 Jan 19;17(1):5-6. PMID: #20129243#