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HRPT2

HRPT2 maps to 1q25-q32 and encodes a novel protein of unknown function called parafibromin.

Pathology

- HRPT2 mutations in hyperparathyroidism-jaw tumor syndrome (HPT-JT syndrome) (#12434154#)
- HRPT2 mutations in 66% of apparently sporadic parathyroid carcinomas
- rare germline mutation in HRPT2 in familial isolated hyperparathyroidism

References

- Tan MH, Teh BT. Renal neoplasia in the hyperparathyroidism-jaw tumor syndrome. Curr Mol Med. 2004 Dec;4(8):895-7. PMID: #15579037#