ADAM28
The A disintegrin and metalloproteinases are a new gene family of proteins (ADAMs) having a metalloprotease domain with matrix metalloproteinases and play an important role in the chondrocyte development process.
Pathology
conventional chondrosarcoma
Low-grade chondrosarcoma and enchondroma are occasionally difficult to differentiate solely by reference to clinicoradiologic and histologic findings.
Overexpression of A disintegrin and metalloproteinase 28 (ADAM28) is increased according to its histologic grade in conventional chondrosarcoma and could be one of the helpful tools in distinguishing between low-grade chondrosarcoma and enchondroma. (#19896699#)
References
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma. Matsuura S, Oda Y, Matono H, Izumi T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M. Hum Pathol. 2009 Nov 6. PMID: #19896699#