CCND2
12p13 HGNC:1583 MIM.123833
The cytogenetic and diagnostic hallmark of mantle cell lymphoma (MCL) is translocation t(11;14)(q13;q32), resulting in overexpression of cyclin D1.
There are rare cyclin D1-negative cases of MCL overexpressing cyclin D2. Anti-cyclin D1 antibodies with low specificity can bind both cyclin D1 and cyclin D2, thus providing false cyclin D1-positive signals in immunohistochemical analysis. (#19783727#)
References
Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected. Stefancikova L, Moulis M, Fabian P, Falkova I, Vasova I, Kren L, Macak J, Smardova J. J Clin Pathol. 2009 Oct;62(10):948-50. PMID: #19783727#