esophageal basaloid squamous cell carcinoma

Basaloid squamous cell carcinoma (BSCC) of the esophagus is rare, historically confused for adenoid cystic carcinoma, and recently shown to behave similar to conventional, keratinizing esophageal squamous cell carcinoma.

At other sites (eg, oropharynx, anogenital tract) the basaloid phenotype is frequently associated with the presence of high-risk human papillomavirus (HPV).

Esophageal BSCC is negative for high-risk HPV by ISH, distinguishing these lesions from other BSCCs. (19738459)

Differential p16 and p53 expression in BSCC suggests that these tumors are molecularly distinct from conventional esophageal squamous cell carcinomas. (19738459)

References

 Basaloid Squamous Cell Carcinoma of the Esophagus: Assessment for High-risk Human Papillomavirus and Related Molecular Markers. Bellizzi AM, Woodford RL, Moskaluk CA, Jones DR, Kozower BD, Stelow EB. Am J Surg Pathol. 2009 Sep 4. PMID: 19738459