osseous perivascular epithelioid cell tumor
Perivascular epithelioid cell tumour (PEComa) is a term applied to a family of mesenchymal tumours composed of varying proportions of spindle and epithelioid cell components associated with HMB-45 expression. PEComa rarely arises in the soft tissue, visceral organs, skin and bone.
Synopsis
epithelioid tumor
nested pattern
areas of nuclear pleomorphism, mitotic activity, necrosis and vascular invasion
HMB-45 expression
References
Malignant perivascular epithelioid cell tumour of the fibula: a report and a short review of bone perivascular epithelioid cell tumour. Lian DW, Chuah KL, Cheng MH, Yap WM. J Clin Pathol. 2008 Oct;61(10):1127-9. PMID: #18820101#