gastroenteropancreatic neuroendocrine tumors
Grading
Three-tiered grading systems (low, intermediate, and high grade) have been proposed for neuroendocrine tumors. A 3-tiered grading classification for gastroenteropancreatic neuroendocrine tumors correlates with survival in the metastatic setting. (#19368957#)
Both mitotic rates and Ki-67 indexes are inversely associated with survival and can be analyzed independently for assignment of grade. (#19368957#)
References
Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumors. Strosberg J, Nasir A, Coppola D, Wick M, Kvols L. Hum Pathol. 2009 Apr 13. PMID: #19368957#