testicular juvenile granulosa tumor
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Epidemiology
<5% pediatric testicular tumors
3–9 years in childhood
Clinical features
Painless unilateral testicular enlargement
Endocrine features may be present
- gynecomastia
- precocious puberty
Macroscopy
Well circumscribed yellow brown nodule
Microscopy
Diffuse sheets of large polygonal cells
- eosinophilic cytoplasm
- Reinke crystals <40%
- regular nuclei, prominent nucleoli
Spindle cell variant
Malignant behavior (10%) associated with:
- >5cm diameter
- cytological atypia
- mitoses
- necrosis
- vascular invasionVariants
Variants
neonatal testicular juvenile-type granulosa tumor (#20592370#, #20445412#)
- most frequent neonatal testicular tumor
See also
juvenile-type granulosa tumor
- ovarian juvenile-type granulosa tumor