metanephric adenofibroma
Microscopical synopsis
intratumoral angiodysplasia
concentric cuffing of entrapped tubules ("onion skinning")
heterologous differentiation
epithelial components
- inactive embryonal epithelium (identical morphologically to metanephric adenoma (MA)
- carcinomatous component distinct from these lesions but identical morphologically to papillary renal cell carcinoma (PRCC).
Prognosis
metastases to the regional lymph nodes at the time of diagnosis (1/9) (#11257617#)
Differential diagnosis
congenital mesoblastic nephroma (CMN) -> intratumoral angiodysplasia, concentric cuffing of entrapped tubules ("onion skinning"), and heterologous differentiation. (#11257617#)
See also
Tumors
- renal tumors
metanephric adenoma
References
Arroyo MR, Green DM, Perlman EJ, Beckwith JB, Argani P. The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center. Am J Surg Pathol. 2001 Apr;25(4):433-44. PMID: #11257617#