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S100s

S-100 proteins (S100s) is a heterogeneous fraction of dimeric polypeptides (alpha and beta subunits) that can exist in different combination forms within the various tissues.

Members

S100As S100A1 S100A2 S100A3 S100A4 S100A5 S100A6 S100A7
S100A8 S100A9 S100A10 S100A11 S100A12 S100A13 S100A14
S100B

Immunochemistry in normal cells

- dendritic cells

  • interdigitating reticulum cells
  • Langerhans cells
  • follicular dendritic reticulum cells

- other S-100-positive cells belonging to the mononuclear/phagocytic system

  • histiocytic neoplasms (#9550310#)

Immunochemistry in tumor cells

- follicular center cell lymphoma

References

- Tomaszewski MM, Lupton GP. Unusual expression of S-100 protein in histiocytic neoplasms.J Cutan Pathol. 1998 Mar;25(3):129-35. PMID: #9550310#