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lipid-laden macrophages

Definition: Macrophages that are laden with lipid (predominantly cholesterol), and that have differentiated from circulating monocytes.

Etiology (Exemples)

- xanthomatous tumors
- histiocytoses

  • Langerhans cell histiocytosis
  • non-Langerhans cell histiocytosis
    • juvenile xanthogranunloma
    • Erdheim-Chester disease

- inherited metabolic diseases

  • lysosomal storage diseases
    • lysosomal acid lipase deficiency
      • Wolman disease

Localization

- renal foamy macrophages

  • glomerular intracapillary foamy macrophages
  • renal tubulary foamy macrophages

- medullary foamy macrophages