ADAM17
MIM.603639 2p25
Following ligand binding, NOTCHs are activated by a series of cleavages that releases its intracellular domain (NICD).
This processing requires the activity of two proteases, namely ADAM17 (tumour necrosis factor-α converting enzyme or TACE MIM.603369) and presenilin-1 (PSEN1 MIM.104311).
See also
NOTCH signaling pathway