protein transport

Types

 vesicle-mediated protein transport

Pathology

 inherited diseases characterized by defects in intracellular protein transport

• defects affecting the protein-sorting apparatus
  • inclusion-cell disease (mucolipidosis II)
  • Hermansky-Pudlak disease
  • Chediak-Higashi disease

• defects in cytoskeletal proteins involved in membrane transport
  • Griscelli disease

• defects in the machinery for the docking and fusion of transport vesicles

 miscellaneous

• COH1 mutations in Cohen syndrome

See also

 vesicle-mediated protein transport

References

 Zimmermann R, Muller L, Wullich B. Protein transport into the endoplasmic reticulum: mechanisms and pathologies. Trends Mol Med. 2006 Dec;12(12):567-73. PMID: 17071140

 Graham TR. Flippases and vesicle-mediated protein transport. Trends Cell Biol. 2004 Dec;14(12):670-7. PMID: 15564043

 Brooksbank C. Protein trafficking. Made for export. Nat Rev Mol Cell Biol. 2001 Feb;2(2):84-5. PMID: 11252962