GDFs
GDFS are a family of proteins that belong to the TGFB superfamily.
TGFB superfamily
The transforming growth factor-beta (TGF-beta) superfamily contains a group of proteins likely to play critical roles in regulating differentiation events during embryonic development.
Members
|GDF1|GDF2 (BMP9)|GDF3|GDF4|GDF5|GDF6|GDF7|GDF8 (MSTN)|
Pathology
GDF1 germline mutations in dextro-looped transposition of the great arteries (MIM.608808), double-outlet right ventricle (DORV) (MIM.217095) with stenosis of the left pulmonary artery and tetralogy of Fallot (MIM.187500).