ADAMs
ADAM proteins (A Disintegrin And Metalloproteinases) are a family of peptidase proteins. ADAMs are also known as the Adamalysin family. It is categorized under EC 3.4.24.46.
ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM10 can cut off part of the HER2 receptor, activating it.
Members of A disintegrin and metalloproteinases (ADAMs)
| ADAM1 | ADAM2 | ADAM3 | ADAM4 | ADAM5 | ADAM6 | ADAM7 | ADAM8 | ADAM9 | ADAM10 |
| ADAM11 | ADAM12 | ADAM13 | ADAM14 | ADAM15 | ADAM16 | ADAM17 | ADAM18 | ADAM19 | ADAM20 |
| ADAM21 | ADAM22 | ADAM23 | ADAM24 | ADAM25 | ADAM26 | ADAM27 | ADAM28 | ADAM29 | ADAM30 |
| ADAM31 | ADAM32 | ADAM33 | ADAM34 |
and ADAMDEC1 ADAM-like, decysin-1
and ADAMTS (disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 protein family)
Pathology
| ADAM9 | expression in pancreatic cancer | #14997207# |
| ADAM33 | genetic susceptibility to asthma | #12683965# |
See also
disintegrins
References
Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Genet. 2000 Feb;16(2):83-7. PMID: #10652535#
Edwards DR, Handsley MM, Pennington CJ (October 2008). The ADAM metalloproteinases. Mol. Aspects Med. 29 (5): 258–89. PMID #18762209#
Wolfsberg TG, Straight PD, Gerena RL, et al. (1995). ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Dev. Biol. 169 (1): 378–383. PMID #7750654#