FMN
MIM.136535 15q13-q14
Function
The formation of cadherin-mediated cell-cell junctions is accompanied by a profound remodeling of the actin cytoskeleton.
The Arp2/3 complex and its activator cortactin (EMS1) drive the assembly of branching actin-filament arrays, and formin (FMN) promotes the nucleation of non-branching actin filaments.
Recruitment of these actin nucleators to nascent adhesions, formation of the links between them and the cytoplasmic cadherin domain, and triggering of their actin-polymerizing functions are vital steps in the development of cell-cell junctions.