ARHGAP20
MIM.609568
Definition: ARHGAP20 is a member of the Rho GTPase-activating proteins (ARHGAPs).
Pathology
disruption of ARHGAP20 and BRWD3 by a t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia (B-cell CLL)
- ARHGAP20 gene at 11q23 (encodes a protein predicted to be involved in the regulation of Rho family GTPases) and BRWD3 at Xq13
- The rearrangement of ARHGAP20 and BRWD3 did not result in fusion transcripts, but it disrupted both genes.
- Deletion of chromosome region 11q22-q23 defines a subgroup of patients with B-cell chronic lymphocytic leukemia (B-CLL) characterized by poor survival.
- The tumor-suppressor gene ATM in the consensus deletion region was found to be biallelically inactivated in about one third of B-CLL cases, in the majority of those who have this deletion, inactivation of the remaining ATM allele was not observed.
See also
BRWDs
ARHGAPs
References
Kalla C, Nentwich H, Schlotter M, Mertens D, Wildenberger K, Dohner H, Stilgenbauer S, Lichter P. Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes. Genes Chromosomes Cancer. 2005 Feb;42(2):128-43. PMID: #15543602#