TFIID
Transcription factor IID (TFIID) is a DNA-binding protein complex required for RNA polymerase II (POLR2A) (MIM.180660)-mediated transcription of many, if not all, protein-encoding genes in eukaryotic cells.
Other general transcription factors are TFIIA (MIM.600519, MIM.600520), TFIIB (MIM.189963), TFIIE (MIM.189962, MIM.189964), TFIIF (MIM.189968), TFIIG/J, and TFIIH (MIM.189972).
TFIID plays a key role in initiation, since it binds to the TATA element to form a complex that nucleates the assembly of the other components into a preinitiation complex and that may be stable through multiple rounds of transcription.
TAF1, or TAFII250, is the largest subunit of TFIID. Other protein subunits of TFIID include TATA box-binding protein (TBP) (MIM.600075) and numerous other TBP-associated factors (TAFs).
TFIID is thought to interact with TFIIA, which may stabilize its binding, and with TFIIB, which is the next factor to enter the complex.
Pathology
- germline mutations of TAF1 in X-linked dystonia-parkinsonism (DYT3) (MIM.314250) (#17273961#)
See also
TAFs
References
Makino S, Kaji R, Ando S, Tomizawa M, Yasuno K, Goto S, Matsumoto S, Tabuena MD, Maranon E, Dantes M, Lee LV, Ogasawara K, Tooyama I, Akatsu H, Nishimura M, Tamiya G. Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism. Am J Hum Genet. 2007 Mar;80(3):393-406. PMID: #17273961#