TAFs
Transcription factor IID (TFIID) is a DNA-binding protein complex required for RNA polymerase II (POLR2A) (MIM.180660)-mediated transcription of many, if not all, protein-encoding genes in eukaryotic cells.
Other general transcription factors are TFIIA (MIM.600519, MIM.600520), TFIIB (MIM.189963), TFIIE (MIM.189962, MIM.189964), TFIIF (MIM.189968), TFIIG/J, and TFIIH (MIM.189972).
TFIID plays a key role in initiation, since it binds to the TATA element to form a complex that nucleates the assembly of the other components into a preinitiation complex and that may be stable through multiple rounds of transcription.
TAF1, or TAFII250, is the largest subunit of TFIID. Other protein subunits of TFIID include TATA box-binding protein (TBP) (MIM.600075) and numerous other TBP-associated factors (TAFs).
TFIID is thought to interact with TFIIA, which may stabilize its binding, and with TFIIB, which is the next factor to enter the complex.
Members
| TAF1 | TAF2 | TAF3 | TAF4 | TAF5 | TAF6 | TAF7 | TAF8 | TAF9 | TAF10 |
| TAF11 | TAF12 | TAF13 | TAF14 | TAF15 |
Pathology
germline mutations of TAF1 in X-linked dystonia-parkinsonism (DYT3) (MIM.314250)
See also
TAFs