ADORA2B
ADORA2B encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily.
This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine.
ADORA2B also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17.
Adenosine receptors (ADORs) serve as important mediators of a diversity of physiologic processes throughout the body. These receptors are members of the G protein-coupled receptor superfamily, a class of cell-surface receptors that, when activated, couple to a heterotrimeric G protein complex to effect signal transduction.
Signaling pathway
A2B receptor-G-protein alpha (Linnea Map1)
A2B receptor-G-protein alpha (Linnea Map2)