RNASEH2C
Ribonuclease (RNase) H enzymes (RNASEHs) specifically cleave ribonucleotides from RNA:DNA duplexes.
Two classes of RNase H (RNASEHs) exist :
type 1 (I): RNASEH1s
type 2 (II): RNASEH2s
The protein complex RNase H2 (RNASEH2s) is the major source of RNase H activity in mammalian cells and yeast.
The protein complex is proposed to function in the removal of lagging-strand Okazaki fragment RNA primers during DNA replication and in the excision of single ribonucleotides from DNA:DNA duplexes.
The 3 homologs in S. cerevisiae are known as Rnh2Ap, Rnh2Bp, and RNh2Cp, respectively.
Pathology
germline mutations in Aicardi-Goutieres syndrome AGS3 (MIM.610329)
See also
| RNASEH1s | |||
| RNASEH2s | RNASEH2A | RNASEH2B | RNASEH2C |
References
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