HOXA9
- HOXA9 is a gene essential to myeloid differentiation that is expressed in PICALM-MLLT10 and MLL-rearranged acute leukemias.
Pathology
overexpression of HOXA9 in tumors
- leukemias (#16518848#)
NB: Constitutive activation of tyrosine kinases by mutations or fusions as BCR-ABL1 could be associated with deregulation of transcription factors central to myeloid differentiation (HOXA9 secondary to PICALM-MLLT10).
References
Sindt A, Deau B, Brahim W, Staal A, Visanica S, Villarese P, Rault JP, Macintyre E, Delabesse E. Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. Genes Chromosomes Cancer. 2006 Jun;45(6):575-82. PMID: #16518848#