MYB

Pathology

 MYB overexpression in colorectal cancer (CRC) is a prognostic indicator for poor survival.

 MYB duplication by dup(6)(q22-q23) in acute lymphoblastic leukemia (ALL)

 MYB-GATA1 fusion gene in acute basophilic leukemia (21474671)

Open References

 Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. Quelen C, Lippert E, Struski S, Demur C, Soler G, Prade N, Delabesse E, Broccardo C, Dastugue N, Mahon FX, Brousset P. Blood. 2011 May 26;117(21):5719-22. PMID: 21474671

References

 Hugo H, Cures A, Suraweera N, Drabsch Y, Purcell D, Mantamadiotis T, Phillips W, Dobrovic A, Zupi G, Gonda TJ, Iacopetta B, Ramsay RG. Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers. Genes Chromosomes Cancer. 2006 Dec;45(12):1143-54. PMID: 16977606