SALL4
SALL4 is a member of the SALs family of proposed C(2)H(2) zinc finger transcription factors. Locus: 20q13
Pathology
SALL4 germline mutations in the Duane radial ray syndrome (Okihiro syndrome) (MIM.607323) (#12395297#)
SALL4 is a novel sensitive and specific marker of ovarian pimitive germ cell tumors and is particularly useful in distinguishing ovarian Yolk sac tumor from ovarian clear cell carcinoma. (#19295406#)
SALL4 is a novel diagnostic marker for testicular germ cell tumors.
- SALL4 is a more sensitive marker than AFP and glypican-3 for yolk sac tumor (endodermal sinus tumor). (#19390421#)
References
Diagnostic Utility of Novel Stem Cell Markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in Primary Mediastinal Germ Cell Tumors. Liu A, Cheng L, Du J, Peng Y, Allan RW, Wei L, Li J, Cao D. Am J Surg Pathol. 2010 May;34(5):697-706. PMID: #20410807#
SALL4 Is a Novel Diagnostic Marker for Testicular Germ Cell Tumors.
Cao D, Li J, Guo CC, Allan RW, Humphrey PA. Am J Surg Pathol. 2009 Apr 22. PMID: #19390421#
SALL4 Is a Novel Sensitive and Specific Marker of Ovarian Primitive Germ Cell Tumors and Is Particularly Useful in Distinguishing Yolk Sac Tumor From Clear Cell Carcinoma. Co D, Guo S, Allan RW, Molberg KH, Peng Y. Am J Surg Pathol. 2009 Mar 17. PMID: #19295406#