cellular mesoblastic nephroma
Etiology
translocation t(12-15)(p13;q25) creating ETV6-NTRK3 gene fusion
See also
pediatric renal tumors
- mesoblastic nephroma
congenital fibrosarcoma
Open access references
ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. Adem C, Gisselsson D, Dal Cin P, Nascimento AG. Mod Pathol. 2001 Dec;14(12):1246-51. PMID: #11743047# [Free]
Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. Argani P, Fritsch M, Kadkol SS, Schuster A, Beckwith JB, Perlman EJ. Mod Pathol. 2000 Jan;13(1):29-36. PMID: #10658907# [Free]
ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Knezevich SR, Garnett MJ, Pysher TJ, Beckwith JB, Grundy PE, Sorensen PH. Cancer Res. 1998 Nov 15;58(22):5046-8. PMID: #9823307# [Free]
Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma. Rubin BP, Chen CJ, Morgan TW, Xiao S, Grier HE, Kozakewich HP, Perez-Atayde AR, Fletcher JA. Am J Pathol. 1998 Nov;153(5):1451-8. PMID: #9811336# [Free]