PVRL2
M.600798 19q13.2
Function
Entry of the poliovirus into permissive cells is dependent on the expression of a specific receptor, the poliovirus receptor (PVR; 173850), which is an integral membrane glycoprotein.
Its extracellular region exhibits 3 immunoglobulin-like domains. Two integral forms, PVR-alpha and PVR-delta, and 2 soluble forms, PVR-beta and PVR-gamma, are lacking a transmembrane region generated by alternative splicing of mRNA. The normal cellular function of PVR is unknown.
Pathology
t(14;19)(q11;q13) in peripheral T-cell lymphoma (PTCL)
- involvement of the TRA@/TRD@ locus at 14q11 and PVRL2 at 19q13 (#17696193#)
NB: Very few recurrent chromosomal abnormalities have been identified in T-cell non-Hodgkin lymphomas. These involve the TRA@/TRD@ gene at chromosome band 14q11 in up to 15% of cases.
References
Almire C, Bertrand P, Ruminy P, Maingonnat C, Wlodarska I, Martin-Subero JI, Siebert R, Tilly H, Bastard C. PVRL2 is translocated to the TRA@ locus in t(14;19)(q11;q13)-positive peripheral T-cell lymphomas.
Genes Chromosomes Cancer. 2007 Aug 15; PMID: #17696193#