EML4/ALK
The fusion gene EML4-ALK was identified in non-small cell lung carcinoma, which could be a potential therapeutic target.
Pathology
ALK/EML4 fusion gene in non-small-cell lung cancer (6.7% of NSCLC) (#17625570#)
Anaplastic lymphoma kinase immunohistochemistry may have utility as a screening tool or as a surrogate marker for the molecular techniques to detect the EML4-ALK fusion gene in these tumors. (#17625570#)
References
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara SI, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007 Jul 11; PMID: #17625570#