ORMDL3

ORMDL3, a member of a gene family that encodes transmembrane proteins anchored in the endoplasmic reticulum.

Pathology

 Genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma. (17611496)

See also

 ORMDLs: ORMDL1, ORMDL2, ORMDL3

References

 Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SA, Wong KC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WO. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.
Nature. 2007 Jul 4; PMID: 17611496

 Katoh M, Katoh M. Identification and characterization of human ZPBP-like gene in silico. Int J Mol Med. 2003 Sep;12(3):399-404. PMID: 12883658

 Hjelmqvist L, Tuson M, Marfany G, Herrero E, Balcells S, Gonzalez-Duarte R. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002;3(6):RESEARCH0027. PMID: 12093374