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spindle assembly checkpoint
Friday 13 July 2007
The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation by preventing cell-cycle progression until all the chromosomes make proper bipolar attachments to the mitotic spindle and come under tension.
See also
mitosis
References
Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol. 2007 May;8(5):379-93. PMID: 17426725
Lengauer C, Wang Z. From spindle checkpoint to cancer. Nat Genet. 2004 Nov;36(11):1144-5. PMID: 15514664