CDC25s
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Members: CDC25A, CDC25B, CDC25C
Functions
Cell division cycle 25 phosphatases (CDC25s) regulate key transitions between cell cycle phases during normal cell division, and in the event of DNA damage they are key targets of the checkpoint machinery that ensures genetic stability.
Pathology
CDC25s proteins overexpression has been reported in a significant number of human cancers.
References
Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer. 2007 Jul;7(7):495-507. PMID: #17568790#
Rudolph J. Inhibiting transient protein-protein interactions: lessons from the Cdc25 protein tyrosine phosphatases. Nat Rev Cancer. 2007 Mar;7(3):202-11. PMID: #17287826#