EWSR1/WT1
Pathology
fusion gene in tumors
- desmoplastic small round cell tumor (DSRCT)
- EWSR1/WT1-associated spindle cell tumor (#17325488#)
References
Alaggio R, Rosolen A, Sartori F, Leszl A, d’Amore ES, Bisogno G, Carli M, Cecchetto G, Coffin CM, Ninfo V. Spindle cell tumor with EWS-WT1 transcript and a favorable clinical course: a variant of DSCT, a variant of leiomyosarcoma, or a new entity? Report of 2 pediatric cases. Am J Surg Pathol. 2007 Mar;31(3):454-9. PMID: #17325488#
Werner H, Idelman G, Rubinstein M, Pattee P, Nagalla SR, Roberts CT Jr. A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Cancer Lett. 2007 Mar 8;247(1):84-90. PMID: #16730884#
Kim J, Lee K, Pelletier J. The DNA binding domains of the WT1 tumor suppressor gene product and chimeric EWS/WT1 oncoprotein are functionally distinct. Oncogene. 1998 Feb 26;16(8):1021-30. PMID: #9519876#